by Stuart Davis | Mar 14, 2023 | Bioinformatics
Introduction In recent years, Next-Generation Sequencing (NGS) technologies have revolutionized the field of genomics, enabling researchers to study the genomes of organisms with unprecedented speed and accuracy. However, the large amounts of data generated by these...
by Stuart Davis | Feb 16, 2023 | Bioinformatics
As academic researchers, we know that the analysis of next-generation sequencing (NGS) data can be complex and time-consuming. The quality of NGS data directly affects the accuracy of downstream analyses, making it essential to ensure that high-quality data is...
by Stuart Davis | Sep 27, 2022 | Bioinformatics
One of the pioneering medical device companies specializing in IVF (In Vitro Fertilization) found itself at a crossroads. They already had a multi-billion dollar portfolio of instruments, assays, and culture media and decided to expand their portfolio to include a...
by Stuart Davis | Sep 12, 2022 | Bioinformatics
Is it necessary to do base quality score recalibration (BQSR) in the GATK pipeline? How should this be done without an available vcf file of known sites? (a) Unfortunately the quality scores produced by next generation sequencing instruments are subject to...
by Stuart Davis | Aug 27, 2022 | Bioinformatics
Cell and Gene Therapy Biotechnology Company Case Study Time is everything for a bioinformatician. With an active R&D group constantly creating new datasets that need to be analyzed, keeping up with their requests is an uphill battle. The newly...
by Stuart Davis | May 7, 2021 | Bioinformatics
Introduction In the quest to understand the very blueprint of life, DNA sequencing stands as a pivotal technology. With the advent of high-throughput sequencing methods, we’ve entered an era where decoding the genetic material is more accessible than ever. This...
